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Melatonin, environmental light, and breast cancer.
Although many factors have been suggested as causes for breast cancer, the increased incidence of the disease seen in women working in night shifts led to the hypothesis that the suppression of melatonin by light or melatonin deficiency plays a major role in cancer development. Studies on the 7,12-dimethylbenz[a]anthracene and N-methyl-N-nitrosourea experimental models of human breast cancer indicate that melatonin is effective in reducing cancer development. In vitro studies in MCF-7 human breast cancer cell line have shown that melatonin exerts its anticarcinogenic actions through a variety of mechanisms, and that it is most effective in estrogen receptor (ER) alpha-positive breast cancer cells. Melatonin suppresses ER gene, modulates several estrogen dependent regulatory proteins and pro-oncogenes, inhibits cell proliferation, and impairs the metastatic capacity of MCF-7 human breast cancer cells. The anticarcinogenic action on MCF-7 cells has been demonstrated at the physiological concentrations of melatonin attained at night, suggesting thereby that melatonin acts like an endogenous antiestrogen. Melatonin also decreases the formation of estrogens from androgens via aromatase inhibition. Circulating melatonin levels are abnormally low in ER-positive breast cancer patients thereby supporting the melatonin hypothesis for breast cancer in shift working women. It has been postulated that enhanced endogenous melatonin secretion is responsible for the beneficial effects of meditation as a form of psychosocial intervention that helps breast cancer patients.
Breast Cancer Res Treat. 2008 Apr;108(3):339-50. Srinivasan V, Spence DW, Pandi-Perumal SR, Trakht I, Esquifino AI, Cardinali DP, Maestroni GJ. Department of Physiology, School of Medical Sciences, University Sains Malaysia, Kubang kerian, Kelantan, 16150, Malaysia.
Release Jealousy To Discover Deeper Relationships Of Trust!This hypnosis session will teach you take back control of your imagination so that you use it for positive visualization, rather than negative suspicions.
I want to start out by saying that it is okay for you to read this article. I know that you will get something out of it and that you are capable of reading it in its entirety. Of course, most people already know this. Clearly they don’t need my permission. However, there are others who seem to always doubt that they have the capability – and the right – to face life’s obstacles no matter how small and insignificant.
Having a recurring feeling of inadequacy or lack of confidence is not good for your health, happiness, or future self-actualization. In order to understand this, realize that...
When a person considers whether maintaining health is a science or art, they normally consider the cultural or prevailing wisdom of the dominant medical institutions. Those institutions, which have legal sanction in our present society, include practitioners who primarily think of themselves as scientists. This is because they have received training that is flavored by scientific tradition. What most people do not realize is that medicine comes in a number of variations. Many of them have roots that precede the establishment of Western scientific thinking. On the other hand, despite the fact...
>Many people have the inability to commit to others. This may be due to many reasons. For instance, they may lack certain social skills due to the failure for the part of their brain, which is involved with empathy and social skills, to develop fully. Also, a lack of nurturing early in life may cause them to be overly defensive.
Our brain is a learning machine that translates perceptions into patterns. In turn, this is reflected by neurological development. The social centers of the brain, which some scientists believe to reside in the lower areas of the parietal lobes, will become fully...