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Management of menopausal symptoms in breast cancer patients.
In breast cancer patients, menopausal symptoms such as hot flashes, urogenital problems, musculoskeletal symptoms and cognitive dysfunction are common, regardless of age at diagnosis. They affect quality of life and systemic therapy will worsen this. Endocrine and/or chemotherapy may induce temporary or permanent ovarian failure and can exacerbate these symptoms. Hormone therapy (HT) has been studied in breast cancer survivors, but safety has been questioned. The HABITS trial investigating estrogen-based HT, as well as the LIBERATE trial investigating tibolone, found a reduction in disease-free survival for those treated. Alternative strategies are needed, as menopause symptoms may reduce compliance with breast cancer treatments. This article reviews recently published strategies to tackle menopausal problems in breast cancer patients. Antidepressants may help with hot flashes. Acupuncture and hypnosis can also be used but the evidence is conflicting. For urogenital problems vaginal moisturizers or topical estrogens can be employed. A musculoskeletal syndrome induced by aromatase inhibitors (AIs) is frequently encountered and currently there are no effective treatment strategies. Bisphosphonates reduce AI-induced bone resorption and can also increase disease-free and overall survival. Standard-dose endocrine and chemotherapy are associated with a decline in cognitive function.
Maturitas. 2010 Dec 22. Loibl S, Lintermans A, Dieudonné AS, Neven P. German Breast Group, GBG Forschungs GmbH, Martin-Behaim-Str. 12, 63263 Neu-Isenburg, Germany.
When your mind and body are relaxing, they are repairing. The largest part of our nervous system, which runs without your conscious awareness, has two modes. When you are in a deep state of relaxation, you are experiencing what is known as a parasympathetic response. This means that your digestion system and other major life-sustaining organs are fully functioning and your immune system is working at its best. The opposite state is called a sympathetic response. Typically those systems and organs that were operating at their best in the parasympathetic mode are now taking a subordinate role...
More than likely you have more to appreciate than you think? I know that for many people times are tough. Too many people are out of work. The Recession has left many of us with a tremendous decrease in income and revenue while our debts and bills remain the same – or are getting worse. However, look around you. If you start a list of everything and everybody that you appreciate in life, you will most likely find that your wealth is much greater than you ever considered.
My favorite Christmas movie is the 1946 Frank Capra movie It’s a Wonderful Life, staring Jimmy Stewart...
Like many other phobias, a fear of heights can be overcome. I know this personally, because it is a phobia that I suffered most of my adult life. Although I did not realize it until I was in my early 40s, it started when I was only four years old. It was then that I observed by older sister fall off a cliff behind our house in France. My father, with the time was a young airman, and several of his friends were able to rescue her. However, during my teen years I began discovering that I had a very significant hesitancy whenever I was asked to do anything involving heights. During my early...